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Senior Scientist, Physicochemical Development

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


Are you ready to make a positive impact on changing patients’ lives? Join our Analytical Sciences team in Biopharmaceuticals R&D, where we play a crucial role in advancing new biopharmaceutical drug projects. We operate in a highly cross-disciplinary environment, collaborating closely with scientists across Biopharmaceutical Development and the wider AstraZeneca organisation.


As a Senior Scientist, you will support the characterization of a broad portfolio of biologics, using state-of-the-art mass spectrometry techniques. You will identify and monitor potential critical quality attributes in support of upstream, downstream and formulation development. You will also explore new technologies/capabilities to enhance our product understanding throughout the manufacturing process. As a subject matter expert, you will be involved in driving our capability build, including proteomics and structural mass-spectrometry. You will represent Analytical Sciences at cross-functional interfaces, both locally and globally.

Essential Skills/Experience:

  • PhD, MSc, BSc (or equivalent) in biochemistry, chemistry or biotechnology with a strong understanding of protein chemistry

  • Experience using LC-MS to characterize sequence variants, post-translational modification analysis and chemical modifications of biologics

  • Proven track record of working collaboratively in a forward-thinking, disruptive and cross-disciplinary/cross-functional environment

  • Experience with leading method qualification and/or tech transfer between multiple sites

  • Confidence in independently developing molecule specific methodology and evaluating new technologies

  • High-quality reporting/presentation of analytical data to non-expert audiences

Desirable Skills/Experience:

  • Practical experience with proteomics workflows along with processing and interpretation of proteomic data sets

  • Practical experience analyzing a range of biotherapeutic modalities, including proteins/nucleic acid/nano particles/virus capsids

  • Experience with physicochemical methods such as N-linked glycan analysis, chromatography (SEC,IEC, RP), electrophoresis (SDS-PAGE and c-IEF) to analyse therapeutic proteins

  • Experience of Biopharmaceutical Development and CMC related activities including experience supporting regulatory filings

  • Familiarity with structural MS (HDX-MS, Native-MS and XL-MS, FPOP)

At AstraZeneca, we follow the science to explore and innovate. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. It's our combination of curiosity and courage that drives us. We celebrate our successes and failures along the way. We work seamlessly as one, expanding our horizons by uniting the best from academia, biotechs and the industry. This is the place to build a meaningful career as we push the boundaries of science to deliver life-changing medicines.

Ready to join us? Apply now to be part of a team that makes a bigger impact on patients' lives!

Date Posted


Closing Date

11-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
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