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Scientist, Physicochemical Development

AstraZeneca UK

Location: Cambridgeshire

Job Type: Full time


Are you ready to make a meaningful impact in the world of biopharmaceuticals? Join our Analytical Sciences team at AstraZeneca, where we play a crucial role in advancing new biopharmaceutical drug projects that change patients’ lives. We operate in a highly cross-disciplinary environment, collaborating closely with scientists across Biopharmaceutical Development and the wider AstraZeneca organization. This is your chance to be part of a team that follows the science unlike anywhere else, pushing boundaries and celebrating both successes and failures along the way.


As a Scientist in our team, you will support the characterization of a broad portfolio of biologics, including mAbs, ADCs, bispecifics, enzymes, mRNA and viruses. You will work collaboratively within the Analytical Sciences team to enhance our product understanding. Your role will involve planning and completing analytical experiments to meet project needs, using mass spectrometry (LC-MS) to characterize protein therapeutics, and reporting high-quality analytical data to non-expert audiences. Are you up for the challenge?

Essential Skills/Experience:

  • BSc (or equivalent), MSc in biochemistry, chemistry or biotechnology with a strong understanding of protein chemistry.

  • Experience planning and/or implementing analytical experiments to meet project needs.

  • Experience with mass spectrometry (LC-MS) to characterize protein therapeutics, including post-translational modifications.

  • Familiarity with some physicochemical methods such as N-linked glycan analysis, chromatography (SEC,IEC, RP), electrophoresis (CE-SDS and c-IEF) to analyse therapeutic proteins.

  • Experience working in a collaborative and fast-paced environment, with strong time management skills.High quality reporting/presentation of analytical data to non-expert audiences.

Desirable Skills/Experience:

  • Practical experience analyzing a range of biotherapeutic modalities, including proteins/nucleic acid/nano particles/virus capsids.

  • Experience with automation, liquid handling robotics and programming languages (Python, R). Familiarity with predictive modeling and machine learning applications would be a plus.

  • Experience of Biopharmaceutical Development and CMC related activities including experience supporting regulatory filings.

  • Experience with tech transfer activities to other sites, including method qualification.

At AstraZeneca, we are unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. It's our combination of curiosity and courage that drives us, inspired by the possibility of doing things that have never been done before. We work seamlessly as one, uniting the best from academia, biotechs and the industry. It's by coming together and leveraging our diverse, global knowledge that we can create the greatest and swiftest impact on disease.

Ready to make a difference? Apply now and join us in our mission to push the boundaries of science to deliver life-changing medicines!

Date Posted


Closing Date

11-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
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