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Senior Scientist - Process Engineer - Chemical Development

AstraZeneca UK

Location: Cheshire East

Job Type: Full time


Senior Scientist - Process Engineer

Macclesfield, UK

Join our Chemical Development team at AstraZeneca, where we believe in pushing the boundaries of science to deliver life-changing medicines. As a Senior Process Engineer, you will be instrumental in designing, developing, and optimising synthetic routes for the active pharmaceutical ingredients of our medicines. You will work closely with a diverse team of engineers, chemists, analysts, and crystallisation scientists to ensure robust and sustainable drug substance manufacture.

As a Senior Process Engineer, your responsibilities will include providing engineering expertise for the development and optimisation of new and established chemical processes. You will carry out scale-up and manufacturability assessments of processes, conduct environmental, materials and process safety assessments, and work closely with our Contract Manufacturing Organisations (CMOs) across the globe. You will also champion sustainability of chemical processes, participate in the overall development of drug substance control strategy, apply technical knowledge to improvement projects, and mentor junior colleagues and university students.

Essential Skills/Experience:
- A degree and / or PhD in Chemical Engineering.
- Experience in pharmaceutical/fine chemical/food manufacturing.
- A well-developed understanding of unit operations such as mixing, distillation, liquid-liquid extraction, isolation and drying and their dependency on scale and equipment.
- Good collaborative skills to enable effective working with different skillsets.
- Good understanding of the requirements, principles and application of process safety and Good Manufacturing Practice (GMP).
- Strong communication and influencing skills.
- Experience of plant manufacture and working with external manufacturers.

Desirable Skills/Experience:
- Experience of chemical process development scale up and / or technical transfer.
- Ability to use modelling software (e.g. Aspen, DynoChem, gPROMS, Computational Fluid Dynamics) to support process understanding.
- Experience working with external suppliers.
- Experience in leading technical projects or acting as a lead process engineer on a project.
- Experience in sustainability improvements e.g. solvent recovery.

At AstraZeneca, we are driven by our commitment to deliver accelerated growth and to make people's lives better. We thrive in our often intense and ambiguous environment, seeking out new challenges and working towards new solutions. We are part of an inclusive and giving community that supports each other on our journeys. We are intellectually stimulated by constant learning and there's potential for multiple, global careers for those who embrace the diverse opportunities. If you have the passion and the drive to accelerate growth and make people's lives better, then this is the place for you.

Are you ready to make a positive impact? Join us in shaping the future of Operations at AstraZeneca! Apply now!

Date Posted


Closing Date

14-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
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