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Translational Science Lead, Immunology and Respiratory

AstraZeneca UK

Location: Cambridgeshire, Gaithersburg, Maryland

Job Type: Full time


Be empowered to be innovative and creative where difference is valued

Join a place built on innovation and creativity. Where different views and perspectives are welcomed and valued. An environment that champions inclusion, and teams that reflect the diversity of the communities that we serve.

Who we are

A high performing team, we are united and motivated by our shared purpose – to deliver life-changing medicines. We come to work each day to make a difference – to patients, society and our company.

What we do

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide.

Why we love it

With our ground-breaking pipeline comes a bright future – a secure job, exciting opportunities and varied work. We’re on an exciting journey to pioneer the future of healthcare.

Main Duties and Responsibilities:

The Early Respiratory and Immunology Translational Science and Experimental Medicine department is a fast-paced environment, with a culture that is both science-based and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population, and to close the gap between bench science and bedside clinical practice.

A key role of Precision Medicine Discovery and Development is to lead the development of precision medicine in immunological and respiratory diseases, driving patient stratification and delivering translational clinical validation, underpinned by the understanding of disease relevant pathways and drivers.

The Translational Science Lead (TSL) is a key scientific and strategic role, where you will be focusing on:

  • Delivering precision medicine strategies to select the patients most likely to benefit from our medicines

  • Building mechanistic understanding of the target and disease through innovative application of experimental methods and technologies.

  • Building the translational clinical validation package for new targets and utilising public and proprietary biobanks, better to understand responding sub populations, biomarkers and the biology of our drug targets

  • Identifying and enabling Proof of Mechanism (PoM) biomarkers to demonstrate target engagement at First-Time-In-Man (FITM)

The TSL is accountable as member of a project team for the precision medicine strategy and clinical target validation strategy. Continuously collaborating with functions within and outwith Early Respiratory and Immunology will be essential continuously to strengthen the link between targets and disease phenotypes and endotypes and bring precision medicine propositions to the clinic. The TSL can be both a laboratory and project role, requiring flexibility to ensure all translational aspects of the projects are supported according to timelines.

Qualifications & Skills:

  • Proven ability to deliver in precision medicine and human target validation and their application to drug discovery

  • Excellent understanding of the Immunology and/ or Respiratory therapy area and disease biology, including related molecular pathways and mechanisms.

  • Experience and knowledge of the biological basis for patient stratification and precision medicine, and also familiar with patient selection biomarker invention and implementation.

  • Experience and knowledge of the biological basis for target engagement biomarkers and familiar with PoM biomarker invention and implementation.

  • Broad understanding of relevant technologies and methodologies along with excellent scientific laboratory skills and ability to experimentally address key scientific questions.

  • Excellent skills in hypothesis forming and testing and able to draw conclusions and suggest next steps based on the experimental data.

  • Shown experience and solid understanding of biology, pharmacology, translational medicine and clinical sciences as well as clinical development with pre-eminence in at least one of these areas.

  • Great leadership skills, ability to be a self-starter.

  • Strong team working skills with a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects.

  • Excellent written, oral, presentation and interpersonal skills

Education Requirements:

  • PhD or MD equivalent with a strong experimental drive and background in relevant scientific field

  • Post-doc experience or otherwise relevant scientific research experience

  • Experience in an academic and/or industry setting

  • Strong publication record

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

So, what’s next?

Are you already imagining yourself joining us? Good, because we can’t wait to hear from you!

Date Posted


Closing Date


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.