Scientist - Translational Pathology, Oncology
Cambridge – 5 days on-site

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death.

Come and join our AZ team where you will play a pivotal role in this exciting period of development.

We are seeking a Scientist to join the Translational Pathology group in the Oncology R&D Translational Medicine department, where you will be at the forefront of the evolution of translational science for the global oncology group at AstraZeneca! You will have the opportunity to impact an industry-leading portfolio of programs from early clinical development of novel therapeutics through to post-marketing opportunities that support approved targeted therapies. At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe!

Key Responsibilities:

In this role, you will work in a Good Clinical Practice (GCP) environment using the best available science and technology to complete routine biomarker analysis and interpret and communicate the data as part of a matrix team. This work will inform clinical decisions for selecting therapeutically relevant doses and schedules, as well as building our understanding of key cancer pathway interactions to guide rational drug combinations. Additionally, your work will help define novel mechanisms of resistance to targeted therapies by studying tumors at relapse.

Requirements:

• BSc or Master’s in a relevant field

• Experience in manual or automated immunohistochemistry (brightfield or fluorescence)

• Experience in microtomy

• Experience working to Good Clinical Practice

• Experience working with human tissues and tissue-based histopathology methods

• Knowledge or experience in one or more AZ portfolio areas: tumour drivers and resistance, DNA damage response (DDR), immuno-oncology (IO) and antibody drug conjugates (ADC)

• Experience of tracking and/or managing human tissues using sample tracking softwares (e.g. BSI, SAPIO, Azenta etc,).
  

Desirables:

• Skilled in development and validation of biomarker assays

• Experience with digital image analysis solutions (e.g. ImageJ, HALO, Visiopharm etc)

• Skills in developing multiplexed immunohistochemistry or in situ hybridization (ISH) assays

• Career exposure to the pharmaceutical industry and the drug development process
  

In Office Requirement:

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of five days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Embrace new and varied opportunities to develop and learn. Here we get to develop and grow, whether that's working at the leading edge or on varied stages and molecules. Working on things that have never been done before. In return, when great science comes alive, we have the opportunity to get published.

Ready to make a difference? Apply now and join us on our journey to push the boundaries of science.

Competitive salary and benefits package on offer.

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Date Posted

27-Nov-2024

Closing Date

03-Dec-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.